North American Veterinary Licensing Examination (NAVLE) Practice Test

In cases of acetaminophen toxicity in cats, the administration of N-acetylcysteine (commonly known as acetylcysteine) is the primary treatment. Acetylcysteine acts as a precursor to glutathione, which is important for detoxifying the harmful metabolites produced during acetaminophen metabolism. Cats are particularly sensitive to acetaminophen due to their limited ability to conjugate the toxic metabolite, leading to oxidative stress and hepatotoxicity.

Alongside acetylcysteine, S-adenosylmethionine (SAMe) is also beneficial since it supports liver function and helps in maintaining hepatic glutathione levels, further aiding in the detoxification process. This combination effectively protects the liver and helps mitigate the effects of the toxicity.

The other treatments listed would not be appropriate for suspected acetaminophen toxicity. Emesis (inducing vomiting) and methylene blue are typically used for other types of poisoning, such as those involving certain hemolytic agents, not acetaminophen. Activated charcoal might be beneficial but is less effective if significant time has passed since ingestion, and whole blood transfusion is reserved for cases of severe hemorrhage or anemia, which is not typical in acetaminophen

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